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Patients who have highly reactive or barrier-impaired skin should introduce any new GHK-Cu copper peptide product gradually and avoid combining it with strong exfoliants, retinoids, or aggressive in-office treatments

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Slow release and K D = 0.90 pM was observed with nitrilotriacetic acid (NTA), whereas His showed fast release and substantially lower K D = 34.7 fM (50 mM HEPES, 50 mM NaCl, pH 7.4), which was explained with formation of ternary HisCuHSA complex

Kareem et al., 2022)